Home > Haematology > ASH 2021 > Myeloproliferative Neoplasms > JAK2V617F variant allele frequency prognostic of venous events in polycythaemia vera

JAK2V617F variant allele frequency prognostic of venous events in polycythaemia vera

Presented By
Dr Giuseppe Loscocco, University of Florence, Italy

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Conference
ASH 2021
JAK2V617F variant allele frequency (VAF) >50% was associated with an increased risk of venous thrombosis in patients with polycythaemia vera (PV). This independent predictor distinguished between patients who were classified as low-risk patients by classical risk modelling, demonstrating that conventional risk assessment may not be sufficient to tailor treatment regarding the prevention of venous thrombosis in patients with PV [1]. “Most patients with PV show a JAK2 mutation in exon 14 (JAK2V617F), and at diagnosis, the JAK2V617F VAF is highly heterogeneous in these patients,” said Dr Giuseppe Loscocco (University of Florence, Italy). “In addition, patients with PV have an increased risk of thrombosis.” Therefore, the current study aimed to evaluate the association between JAK2V617F VAF at diagnosis and the rate of arterial and venous thrombosis. In total, 865 cases were analysed. ...


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