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Lifelong patterns of clonal haematopoiesis revealed

Presented By
Dr Margarete Fabre, University of Cambridge, UK
ASH 2021
A study into the natural history of clonal haematopoiesis revealed that different gene mutations drive different patterns of lifelong clonal behaviour, with DNMT3A, TET2, and spliced mutant clones being the most common drivers. Moreover, the share of oligoclonal clones increases with age. The current characterisation of lifelong natural clonal haematopoiesis offers insights into the interaction between somatic mutations, ageing, and clonal selection [1]. “In normal haematopoiesis, stem cells are homogenous, whereas in clonal haematopoiesis stem cells are genetically diverse due to acquired somatic mutations,” Dr Margarete Fabre (University of Cambridge, UK) explained. “We conducted a study to unravel the transition from normal to clonal haematopoiesis and map the dynamics of clonal haematopoiesis.” Dr Fabre and colleagues assessed 13 years of blood samples, collected from an elderly population (n=385; mean age at baseline 69.3 year...

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