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Mechanisms behind TP53 mutations revealed in myeloproliferative neoplasms

Presented By
Dr Alba Rodriguez-Meira, University of Oxford, UK
ASH 2021
A single-cell, multi-omics analysis into the mechanisms behind TP53-mediated transformation of haematological malignancies towards acute leukaemia revealed novel aspects of the genetic, cellular, and molecular changes that occur during this transformation. Since TP53 mutations are common, these results may have relevance for other cancer types [1]. Multi-hit TP53 mutations are associated with treatment resistance and a worse prognosis in myeloid malignancies. Therefore, Dr Alba Rodriguez-Meira (University of Oxford, UK) and colleagues aimed to unravel the biological basis of TP53-mediated transformation of haematological malignancies. Since myeloproliferative neoplasms (MPN) frequently progress towards secondary acute myeloid leukaemia (AML) due to TP53 missense mutations, the team performed single-cell, multi-omic TARGET-seq analysis of haematopoietic stem and progenitor cells (HSPCs) (n=22,116) in 26 patients ...

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