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Reduced risk of Alzheimer’s disease in CHIP carriers

Presented By
Dr Hind Bouzid, Stanford University, CA, USA
ASH 2021
Clonal haematopoiesis of indeterminate potential (CHIP) was associated with decreased risk of Alzheimer’s disease (AD) and AD neuropathological changes. Mutated haematopoietic stem cells were detected in the brains of CHIP carriers. These mutated cells supplemented the microglial pool in ageing individuals, potentially reducing the risk of AD via improved amyloid and tau clearance [1]. “CHIP has been associated with haematologic malignancies, atherosclerosis, and increased mortality,” explained Dr Hind Bouzid (Stanford University, CA, USA). The current study investigated the relation between CHIP and neurodegenerative disease via a longitudinal cohort study, a case-control study, a mendelian randomisation, and a brain pathology assessment. The longitudinal cohort study included 3,180 patients, including 258 patients with confirmed AD, and assessed the relation between AD and CHIP. The analysis demonstrated that CHIP carriers had a r...

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