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Sustained remission after TPO-RA discontinuation in chronic ITP

Presented By
Prof. Matthieu Mahevas, HĂ´pital Henri-Mondor, France
ASH 2021
High rates of sustained remission were achieved in patients with chronic primary immune thrombocytopenia (ITP) who discontinued thrombopoietin-receptor agonist (TPO-RA) therapy after achieving a complete response (CR). The results of the STOPAGO study support progressive dose reductions of TPO-RAs in patients who achieved a stable CR on this treatment [1]. A recent prospective study observed durable remissions in approximately 30% of the patients with ITP after TPO-RAs discontinuation [2]. However, the study population included patients with newly diagnosed ITP, in whom spontaneous remission may occur. Therefore, Prof. Matthieu Mahevas (HĂ´pital Henri-Mondor, France) and colleagues conducted the prospective, multicentre, interventional STOPAGO study (NCT03119974) to assess the proportion of patients with chronic or persistent ITP that display sustained remission aft...

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