Home > Haematology > Novel immunotherapy for cancer takes cue from transplant rejection

Novel immunotherapy for cancer takes cue from transplant rejection


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Journal
Nature Biotechnology
Reuters Health - 15/12/2021 - A novel immunotherapy treatment works by triggering genetically modified T cells to reject cancer, much as they would a transplanted organ, researchers say. The approach was effective in mouse models and in leukemia cells from patients. "Our results show that it is possible to identify therapeutic T-cell receptors (TCRs) that can efficiently 'see' targets inside cancer cells that the immune system normally tolerates, by exploiting the mechanism of transplant rejection," Dr. Johanna Olweus of Oslo University Hospital Radiumhospitalet and the University of Oslo told Reuters Health by email. "This opens the possibility to develop efficient gene therapies for many other cancer types." "By targeting molecules inside the cell that are unique to the cell type, many more targets become accessible as compared with the limited number of molecules that are available on the outside of the cancer cell," she explained. As reported in Na...


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