Home > Neurology > AAN 2022 > Multiple Sclerosis > Ketogenic diet may improve disability and quality of life

Ketogenic diet may improve disability and quality of life

Presented By
Dr James Nicholas Brenton, University of Virginia Medical Center, VA, USA
AAN 2022
A new study has found that a ketogenic diet is safe and tolerable over 6 months in patients with relapsing multiple sclerosis (MS) and has potential benefits. In a study with 65 participants, a ketogenic diet yielded improvements in body composition, fatigue, depression, quality of life, and neurological disability. High-fat, low-carbohydrate ketogenic diets mimic a fasting state and have previously been shown to affect immune regulation, as explained by Dr J. Nicholas Brenton (University of Virginia Medical Center, VA, USA) [1]. To investigate the possible therapeutic potential of ketogenic diets, an open-label, uncontrolled study was set up that included 65 MS patients. They followed a ketogenic diet for 6 months and adherence was monitored on a daily basis by urine ketone testing. Patient-reported fatigue, depression, and quality-of-life scores were measured at baseline, as well as MS-related clinical outcome metrics. Baseline study metrics we...

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