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Ketogenic diet may improve disability and quality of life

Presented By
Dr James Nicholas Brenton, University of Virginia Medical Center, VA, USA
Conference
AAN 2022
Doi
https://doi.org/10.55788/a34e5b51
A new study has found that a ketogenic diet is safe and tolerable over 6 months in patients with relapsing multiple sclerosis (MS) and has potential benefits. In a study with 65 participants, a ketogenic diet yielded improvements in body composition, fatigue, depression, quality of life, and neurological disability. High-fat, low-carbohydrate ketogenic diets mimic a fasting state and have previously been shown to affect immune regulation, as explained by Dr J. Nicholas Brenton (University of Virginia Medical Center, VA, USA) [1]. To investigate the possible therapeutic potential of ketogenic diets, an open-label, uncontrolled study was set up that included 65 MS patients. They followed a ketogenic diet for 6 months and adherence was monitored on a daily basis by urine ketone testing. Patient-reported fatigue, depression, and quality-of-life scores were measured at baseline, as well as MS-related clinical outcome metrics. Baseline study metrics we...


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