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Benign prostatic hyperplasia tied to Alzheimer’s disease risk


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Journal
EClinicalMedicine
Reuters Health - 16/02/2021 - Men with benign prostatic hyperplasia have an elevated risk of developing Alzheimer's disease and all-cause dementia, according to researchers who speculate that disturbed sleep may be a contributing factor. The study examined data on 297,026 Danish men with benign prostatic hyperplasia (BPH) who were identified based on surgical or medical treatment for the condition, as well as a control group of 1.12 million men in the general Danish population without BPH matched by birth year. Median follow-up starting one year after the prostate diagnosis or index date was 6.9 years for men with BPH and 6.4 years for the comparison group. During the study period, a total of 7,909 men with BPH developed incident dementia from any cause, including 3,603 cases of Alzheimer's disease, compared with 24,745 men in the general population cohort who developed dementia, and 9,946 who had Alzheimer's. The cumulative risk of Alzheimer's disease from y...


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