Home > Neurology > Drugs that boost neurotrophic support might be helpful in early dementia

Drugs that boost neurotrophic support might be helpful in early dementia


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Journal
JAMA Neurology
Reuters Health - 31/01/2022 - A naturally occurring polymorphism in brain-derived neurotrophic factor may be an important moderator of cognitive impairment and levels of site-specific tau phosphorylation in dominantly inherited Alzheimer disease (DIAD), new research suggests.  DIAD is a rare form of AD that causes memory loss and dementia in people typically in their 30s, 40s and 50s.  In presymptomatic DIAD, polymorphism in the brain-derived neurotrophic factor (BDNF) gene resulting in a valine (Val) to methionine (Met) substitution at codon 66 (BDNF Val66Met) has been shown to moderate increases in cerebrospinal fluid levels of tau and phosphorylated tau 181 ...


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