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Biomarkers and how to use them

EAN 2019
Biomarkers are diagnostic tools that can detect disease-specific alterations in the brain. Depending on what moment in the disease process these alterations occur, biomarkers are more suitable for early or differential dementia diagnosis. Ideal biomarkers also allow monitoring of disease progression. Optimisation of existing biomarkers, as well as the development of novel biomarkers, is required to improve early and differential dementia diagnosis. Synaptic dysfunction is the best correlate of cognitive impairment that precedes neuronal cell death in patients along the Alzheimer’s disease (AD) continuum. EEG topographical markers were found to correlate with surrogate synaptic markers and therefore contribute to early detection of synaptic dysfunction in patients along the AD continuum [1]. In both patients diagnosed with mild cognitive impairment (MCI, n=40) and AD (n=20), the pattern of regional brain glucose hypometabolism correla...

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