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The role of neurogenic inflammation in migraine

Presented By
Prof. Lars Edvinsson, Lund University, Sweden
Conference
EAN 2019
In his plenary lecture, Prof Lars Edvinsson (Lund University, Sweden) discussed the evidence for a role of neuroinflammation in initiation of a migraine attack; the possibility of neurogenic inflammation caused by subsequent antidromic neuropeptide release during an attack (predominantly calcitonin gene-related peptide (CGRP); and the novel concept of neurogenic neuroinflammation in migraine chronification [1]. “It has taken me 35 years to convince the world of the important role CGRP plays in migraine”, Prof. Edvinsson said. He has always believed migraine to be a brain disease, a disorder in which CNS dysfunction plays a pivotal role: “Migraine symptoms all come from the brain.” The trigeminal ganglion (TG) plays a key role in primary headache pathophysiology, being central to the trigeminovascular reflex, which is triggered to protect against vasoconstriction. The triggering of this system leads to the perception of pain in patients with migraine. CGRP ...


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