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Risk factors for conversion to secondary progressive MS

Presented By
Dr Pietro Iaffaldano, University of Bari Aldo Moro, Italy
To date, according to the Lublin definition, secondary progressive MS and its diagnosis are retrospective, based on a history of gradual EDSS worsening [1,2]. There are no clear metrics for sensitive and reliable identification of the transition from relapsing-remitting MS to secondary progressive MS available to assist neurologists in daily clinical practice. In 2016, an objective definition of secondary progressive MS was proposed, based on the application of a mathematical algorithm to longitudinally recorded EDSS score evaluations in the MSBase platform [3]. Caution should be taken, because the way conversion is defined may affect the risk and protective factors eventually associated with the disease course transition. So far, no studies have evaluated the risk factors for conversion using different secondary progressive MS definitions. In a large cohort of relapsing-remitting MS patients (n=19,318) extracted from the Italian MS Registry, two di...

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