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Interictal pontine metabolism in migraine patients without aura

Presented By
Dr Samaira Younis, Danish Headache Centre, Denmark
IHC 2021
Migraine is not associated with altered interictal pontine glutamate levels. Interestingly, interictal total creatine levels were increased in the pons. This novel finding from a Danish imaging study suggests that disequilibrium in the pontine energy metabolism could be an important feature of migraine pathophysiology [1]. The major excitatory neurotransmitter glutamate is involved in the trigeminovascular pain pathway. In the pons, glutamatergic mechanisms are involved in regulating inhibitory descending pain modulation and serotoninergic neurotransmission, as well as modulating the sensory transmission of the trigeminovascular system. Abnormal glutamate levels in the pons may be an important pathophysiological feature of migraine, aiding to attack initiation. “How to measure glutamate levels in the pons? This is technically challenging,” Dr Samaira Younis (Danish Headache Centre, Denmark) mentioned. “In recent years, however, the applic...

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