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Neuroinflammation common in familial frontotemporal dementia


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Journal
Journal of Neurology, Neurosurgery and Psychiatry
Reuters Health - 26/11/2020 - Neuroinflammation appears to be a typical feature of the three most common monogenic forms of familial frontotemporal dementia (FTD), according to a new case series from the U.K. Based on this finding, the authors suggest that "future disease-modifying treatment strategies may be enhanced by immunomodulation" and that positron emission tomography (PET) studies in presymptomatic carriers of one of the three genes "could help develop early, targeted, interventions." One-fifth of FTD cases are autosomal dominant and typically arise from mutations in the GRN, MAPT or C9orf72 genes, Dr. James Benedict Rowe of the University of Cambridge and colleagues note in the Journal of Neurology, Neurosurgery and Psychiatry. Some evidence, they add, suggests that neuroinflammation may be an early pathogenic process, rather than a result of neurodegeneration. In a previous PET study by some of the researchers, neuroinflammation in one form of FTD ...


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