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Pre-treatment brain activation pattern tied to therapy response in OCD


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Journal
American Journal of Psychiatry
Reuters Health - 30/09/2020 - People who receive cognitive behavioral therapy (CBT) for obsessive compulsive disorder (OCD) experience greater symptom reduction when they have higher levels of activity in certain regions of the brain prior to treatment, a recent study suggests. Researchers randomly assigned 87 patients with OCD ranging in age from 12 to 45 years to receive 12 weeks of either CBT or stress management therapy (SMT). Prior to treatment, participants received functional MRI scans while performing an incentive flanker task designed to assess brain activation to reward processing and cognitive control. Participants randomized to CBT had a better treatment response when their pre-treatment MRI showed greater activation within the ventromedial prefrontal, orbitofrontal, lateral prefrontal and amygdala regions during reward processing and within the right temporal lobe and rostral anterior cingulate during cognitive control. In contrast, participants ...


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