Home > Neurology > Senescent cells with neurofibrillary tangles identified as potential Alzheimer’s treatment target

Senescent cells with neurofibrillary tangles identified as potential Alzheimer’s treatment target


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Journal
Nature Aging
Reuters Health - 23/12/2021 - Senescent cells with tau-containing neurofibrillary tangles (NFTs) could be a treatment target for Alzheimer's disease (AD), researchers suggest. Senescent cells function abnormally and release toxic substances that kill surrounding healthy cells and cause inflammation. They build up over time, contributing to the aging process, neurocognitive decline and cancer. Earlier work by Dr. Miranda Orr of Wake Forest School of Medicine in Winston-Salem and colleagues found that senescent cells accumulated in mouse models of AD, and that the cells could be cleared, halting disease progression. Now, in an upcoming phase 2 trial, the broad-spectrum tyrosine kinase inhibitor dasatinib, which is approved to treat leukemia, will be tested at a different dose and schedule to see if it can help clear the senescent cells, Dr. Orr told Reuters Health by email. The first study subject is scheduled to be screened at Wake Forest during Christmas week...


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