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Sleep EEG-based brain-age index correlates with dementia


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Journal
JAMA Network Open
Reuters Health - 08/10/2020 - A brain-age index (BAI) based on sleep electroencephalography (EEG) shows promise as a biomarker for dementia, new findings show. Using machine learning to analyze more than 5,000 polysomnograms, Dr. Alice D. Lam of Massachusetts General Hospital in Boston and her colleagues found BAI - a measure of brain age in relation to chronological age - correlated significantly with dementia and measures of global cognition. "Many people undergo polysomnography for clinical purposes, such as to evaluate for sleep apnea or other sleep disturbances. The BAI is a method that extracts additional information from a polysomnogram, which could potentially serve as a preliminary screen for individuals who might be at risk for developing dementia," Dr. Lam told Reuters Health by email. She and her colleagues retrospectively analyzed polysomnograms from 5,144 patients 50 and older, who they categorized into five groups: healthy (2,336 patients based...


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