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Study supports use of hypertonic saline in pediatric TBI


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Journal
JAMA Network Open
Reuters Health - 31/03/2022 - In children with severe traumatic brain injury (TBI), giving a bolus of hypertonic saline is associated with "a significant, albeit relatively modest, reduction" in intracranial pressure during the initial hour of treatment, while bolus mannitol is not, according a new study.  "Hyperosmolar agents are cornerstone therapies for pediatric severe traumatic brain injury," researchers note in JAMA Network Open, but the evidence for using hypertonic saline (HTS), let alone mannitol, is weak.  To investigate, Dr. Michael Bell of Children's National Hospital in Washington, D.C., and colleagues analyzed data from eight countries on 1,000 co...


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