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Tau buildup in brain tied to psychosis, more rapid decline in Alzheimer’s disease


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Journal
Translational Psychiatry
Reuters Health - 11/03/2022 - Increased concentrations of the tau protein in the brain's frontal, medial and occipital cortices are associated with psychosis and more rapid cognitive and functional decline in Alzheimer's disease (AD) patients, an imaging study shows.  Dr. Jeremy Koppel of the Feinstein Institutes for Medical Research in Manhasset, New York, told Reuters Health by email, "Psychosis in AD may represent a unique kind of tauopathy, similar... to the way chronic traumatic encephalopathy is a unique tauopathy - different under the microscope from Alzheimer's disease."  "Studies need to look closer at distinguishing this syndrome from non-psychotic AD...


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