Home > Oncology > ASCO GU 2022 > Renal Cell Carcinoma > Differential patterns of molecular alterations among sites of metastasis in RCC

Differential patterns of molecular alterations among sites of metastasis in RCC

Presented By
Dr Rana McKay, University of California San Diego, CA, USA
Conference
ASCO GU 2022
Molecular features differ between primary and distant metastases in patients with renal cell carcinoma (RCC), according to a real-world analysis of 657 RCC samples. RCC has a distinct pattern of metastatic spread with common sites of metastasis including the lung, bone, and liver [1]. Less common sites include the brain, adrenal gland, and pancreas. The site of metastasis is prognostic in RCC [2]. To get more insight into the biology driving tropism to specific organ sites, molecular features were characterised from RCC metastases across various metastatic sites. Dr Rana McKay (University of California San Diego, CA, USA) presented the results [3]. A total of 657 RCC samples derived from the kidney and distant metastatic sites from 653 patients underwent molecular profiling. The most common histology was clear-cell RCC (77.3%), followed by papillary (9.6%), chromophobe (4.6%), medullary (1.2%), collecting duct (0.9%), and mixed (6.2%). Specimen sou...


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