Home > Oncology > Implanted system rapidly generates CAR-T cells to combat tumors in mice

Implanted system rapidly generates CAR-T cells to combat tumors in mice


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Journal
Nature Biotechnology
Reuters Health - 04/04/2022 - An implantable system can both produce and release CAR-T cells in the body to combat cancer, a mouse study shows. The system, called MASTER (Multifunctional Alginate Scaffolds for T cell Engineering and Release), is a biocompatible, sponge-like material decorated with antibodies. When it comes in contact with patient T cells combined with an engineered virus, the T cells become activated and the engineered virus reprograms them into CAR-T cells. MASTER is also impregnated with interleukins that foster proliferation. After implantation, these interleukins begin to leach out, promoting rapid proliferation of the CAR-T cells. "CAR-T cell production currently involves a sequence of laborious steps, each requiring different biological signals," Dr. Yevgeny Brudno of North Carolina State University in Raleigh told Reuters Health by email. "Biomaterials can present each of these signals to the cells, enabling the manufacturing process t...


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