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Liver metastases suppress tumor-specific immunity


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Journal
Science Immunology
Reuters Health - 02/11/2020 - Liver metastases suppress tumor-specific immunity and contribute to resistance to checkpoint-inhibitor immunotherapies (CPIs), researchers report. "We found it surprising that tumor presence within the liver can have such a striking influence on the phenotype of tumor-specific CD8 effector T cells at a distant tumor site," said Dr. James C. Lee of the University of California, San Francisco. "We also found the highly precise and tumor antigen-specific suppression surprising, but this clued us in on the involvement of a highly sophisticated liver-specific regulatory process," he told Reuters Health by email. In malignancies where CPIs have shown efficacy, the presence of liver metastases appears to reduce response rates and survival. It remains unclear how liver metastases modulate systemic antitumor immunity and contribute to CPI resistance. Dr. Lee and colleagues earlier showed that the presence of liver metastases in pat...


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