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New tool helps predict chemotherapy toxicity in older women with early breast cancer


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Journal
Journal of Clinical Oncology
Reuters Health - 14/01/2021 - Researchers have developed and validated a simple risk-assessment tool that combines eight clinical and geriatric factors to gauge the likelihood of severe side effects from chemotherapy in older women with early-stage breast cancer. "The decision to pursue chemotherapy as an older patient is complex," Dr. Mina Sedrak, co-first author and deputy director of clinical trials for the Center for Cancer and Aging Research at City of Hope in Duarte, California, told Reuters Health by email. "We hope that this tool, along with clinical judgment and patient preferences, will improve the care that older adults with early-stage breast cancer receive," Dr. Sedrak said. The Cancer and Aging Research Group-Breast Cancer (CARG-BC) Score was developed and validated in 473 women (283 in development and 190 in validation cohort) aged 65 and older with stage-I to -III breast cancer treated with neoadjuvant or adjuvant chemotherapy. Overall,...


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