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Home > Oncology > SABCS 2021 > Triple-Negative Breast Cancer > Single-cell spatial analysis can predict response to neoadjuvant immunotherapy

Single-cell spatial analysis can predict response to neoadjuvant immunotherapy

Presented By
Dr Giampaolo Bianchini, Ospedale San Raffaele, Italy
Conference
SABCS 2021
Trial
Phase 3, NeoTRIPaPDL1
A next-generation technology that allows the study of protein expression at the single-cell level and the location of the cells to be within the tumour microenvironment was feasible and provided information on the benefit of adding the immune checkpoint inhibitor atezolizumab to chemotherapy as neoadjuvant treatment for patients with early high-risk and locally advanced triple-negative breast cancer (TNBC). Immune checkpoint inhibitors are effective in early and advanced TNBC. However, only a minority of patients benefit from it, making precision immuno-oncology a major unmet need. Imaging mass cytometry enables high dimensional tissue imaging at subcellular resolution for assessment of TNBC ecosystems, providing information on cell type composition, functional status, and spatial organisation. Dr Giampaolo Bianchini (Ospedale San Raffaele, Italy) and colleagues investigated whether imaging mass cytometry could assist in the identification of ide...


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