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Trade-offs to skipping radiotherapy after breast-conserving surgery in older women


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Conference
2020 San Antonio Breast Cancer Symposium
Reuters Health - 10/12/2020 - Older women with hormone-receptor-positive breast cancer who skipped radiation therapy (RT) after breast-conserving surgery had higher rates of local recurrence but similar survival rates relative to their peers who had RT after surgery, according to 10-year data from the PRIME II study. "We found that omitting postoperative radiation therapy did not compromise survival or increase the risk of distant metastasis," Dr. Ian Kunkler of the University of Edinburgh said in a news release from the 2020 San Antonio Breast Cancer Symposium where he presented the data. Based on these results, omission of postoperative radiation after breast-conserving surgery is a "reasonable option" for older women with localized, HR-positive breast cancer who are receiving adjuvant hormone therapy and meet certain clinico-pathological criteria, Dr. Kunkler told the conference. The PRIME II study enrolled 1,326 women aged 65 and older with localized, HR-...


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