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Genomics of vascular dementia and stroke

Presented By
Prof. Elisabeth Tournier-Lasserve, Saint Louis Hospital, France
ECNP 2020
Cerebrovascular diseases are very heterogeneous from both a clinical and an aetiopathogenetic point of view. These diseases can lead to epilepsy, vascular dementia, cerebral infarcts, or haemorrhages. Some of these diseases affect large cerebral vessels while others affect small cerebral vessels, which may result in cerebral small vessel disease (cSVD) [1]. cSVD is a term used by neurologists to designate several small arteries diseases (40-200 mm), such as superficial perforating arteries and deep basal ganglia perforating arterioles. These diseases are responsible for 20-30% of stroke cases in adult patients (both ischaemic and haemorrhagic), according to Prof. Elisabeth Tournier-Lasserve (Saint Louis Hospital, France). Furthermore, cSVD is the main cause of vascular dementia, which is the second most common cause of dementia. Small vessels are not visible on MRI or CT scans. Only the consequences of small vessel disease can be perceived: hypersi...

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