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Heart rate could be a potential biomarker for depression

Presented By
Dr Carmen Schiweck, Goethe University, Frankfurt
ECNP 2020
  In a small proof-of-concept study, measuring changes in 24-hour heart rate indicated with ~90% accuracy whether an individual suffered from depression. Future longitudinal studies with larger sample sizes are needed to further to gain more insight in heart rate as marker for antidepressant treatment approaches. Dr Carmen Schiweck (Goethe University, Frankfurt) explained: “An innovative study design with the rapid-acting antidepressant ketamine was designed to assess the potential of heart rate or heart rate variability as state marker for depression. We aimed to assess the potential of real-life psychophysiological measures as state markers for depression” [1]. Two innovative elements in this study were the continuous registration of heart rate for several days and nights, as well as the new antidepressant ketamine, which has a fast onset of action. The average resting heart rate may change quite sudd...

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