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rTMS is not effective in OCD

Presented By
Dr Alper Zıblak, Pamukkale University, Turkey
ECNP 2020
Repetitive transcranial magnetic stimulation (rTMS) applied in the orbitofrontal cortex (OFC) is not effective as add-on treatment in obsessive-compulsive disorder (OCD) in a relatively large patient group compared with previous studies conducted in this field [1]. Previous studies show that high-frequency stimulation of the anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) is effective in treatment [2,3]. Dr Alper Zıblak (Pamukkale University, Turkey) explained the hypothesis for this treatment. OFC activation is increased by provoking symptoms in OCD patients. Moreover, improvement of OCD symptoms with selective serotonin reuptake inhibitors (SSRIs) or cognitive behavioural therapies is associated with decreased OFC activation. This indicates that methods to decrease OFC activation may be effective in the treatment of patients suffering from OCD. However, there is hardly any data available on this particular topic. Dr Zıblak and ...

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