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CPAP withdrawal has negative consequences for sleep apnoea patients

Presented By
Prof. David Kim, Johns Hopkins University, USA
ERS 2020
In a randomised, crossover study, withdrawal of continuous positive airway pressure (CPAP) led not only to a worsening sleep apnoea but also to an increase in arterial stiffness [1]. Obstructive sleep apnoea (OSA) is highly prevalent and is associated with increased arterial stiffness. Changes in the mechanical properties of the vessel wall related to arterial stiffening may activate several mechanisms that are also involved in the process of atherosclerosis [2]. Indeed, arterial stiffness has been shown to be associated with incident of cardiovascular events and all-cause mortality [2]. It can be measured by systolic augmentation of the pulse wave and is assessed by the heart rate-corrected augmentation index (AIx). Prof. David Kim and his co-workers (Johns Hopkins University, USA) assessed whether CPAP withdrawal will increase augmentation index and how this risk factor is affected by sleep apnoea severity, age, BMI, sex, and diabetes. Patients wi...

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