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Lung-cancer salvage surgery might help after TKI treatment


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Journal
Lung Cancer
Reuters Health - 29/01/2021 - Salvage surgery might be beneficial in patients with recurrent or residual non-small-cell lung cancer following tyrosine-kinase inhibitor (TKI) treatment, according to a small retrospective study from Japan. Molecular targeted therapies such as epidermal growth factor receptor (EGFR)-TKI or anaplastic lymphoma kinase (ALK)-TKI have dramatically changed clinical outcomes in such patients with driver-gene alterations, Dr Kimihiro Shimizu of Shinshu University School of Medicine, in Matsumoto, and colleagues note in Lung Cancer. However, they add, "TKI treatments rarely lead to tumor remission; even if tumors undergo complete response, they virtually always acquire resistance to TKI after a while and become a systemic disease." But if tumor spread is limited to the thorax, salvage surgery might present a therapeutic option, the team says. To investigate, the researchers examined data covering 2010 to 2015 on perioperative and postop...


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