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No benefit of adding metformin to chemoradiotherapy in locally advanced lung cancer


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Journal
JAMA Oncology
Reuters Health - 05/08/2021 - Two studies have found no benefit of adding metformin to chemoradiotherapy in non-diabetic patients with inoperable locally advanced non-small-cell lung cancer (NSCLC). "The findings of both studies are surprising and particularly more so those of the Canadian trial (OCOG-ALMERA)," which found worse outcomes and increased toxicity in the metformin group, Dr. Theos Tsakiridis of Juravinski Cancer Center, McMaster University, in Hamilton, Canada, told Reuters Health by email. However, "we believe that the association of metformin with inferior outcomes in OCOG-ALMERA is a chance finding that is influenced by the small sample size in this trial. We do not think that metformin is toxic to patients with NSCLC. This was demonstrated in NRG-LU001 trial," Dr. Tsakiridis said. Both studies were published in JAMA Oncology. The NRG-LU001 trial compared taxane-based chemoradiotherapy and consolidation chemotherapy alone (control) or w...


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