Home > Pulmonology > Three-drug combination bests older therapy in some patients with cystic fibrosis

Three-drug combination bests older therapy in some patients with cystic fibrosis


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Journal
The New England Journal of Medicine
Reuters Health - 25/08/2021 - Triple-drug therapy with elexacaftor, tezacaftor and ivacaftor produces better outcomes in cystic fibrosis patients who have one Phe508del defect and either a gating or residual function defect compared with treatment with tezacaftor and ivacaftor, or ivacaftor alone, a new study has concluded. Eight weeks of the three-drug combination produced higher scores in predicted forced expiratory volume (FEV-1), lower sweat chloride concentrations, and higher scores on a quality-of-life questionnaire versus conventional therapy. In some cases, the newer treatment produced test results that were in the range of people who don't have CF at all. Vertex Pharmaceuticals, which sells the three-drug combination under the brand names Trikafta and Kaftrio, financed the test of 258 volunteers, the results of which are published in The New England Journal of Medicine. More than 80,000 people worldwide suffer with CF and more than 1,000 genet...


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