Home > Rheumatology > ACR 2021 > COVID-19: What You Need to Know > COVID-19 mRNA vaccine safe and tolerable in adults with autoimmune disease

COVID-19 mRNA vaccine safe and tolerable in adults with autoimmune disease

Presented By
Dr Inés Colmegna, McGill University Health Centre, Canada
Conference
ACR 2021
A Canadian study revealed that the Moderna mRNA-1273 SARS-CoV-2 vaccine is safe in immunocompromised adults with autoimmune disease and not associated with severe disease flares. Interestingly, patients with rheumatoid arthritis (RA) ≥65 years had similar immune responses compared with younger patients. Immunocompromised patients or those with a history of autoimmune disease have mainly been excluded from clinical vaccination trials against COVID-19. Therefore, a Canadian study (NCT04806113) assessed the safety and efficacy of 2 doses of the mRNA-1273 SARS-CoV-2 vaccine in patients with autoimmune diseases [1,2]. “Our study was designed as a prospective, randomised, open-label comparative trial that was conducted at 2 centres,” Dr Inés Colmegna (McGill University Health Centre, Canada) said. The safety of the vaccine was the primary outcome. The researchers also as...


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