Home > Rheumatology > ACR 2021 > Psoriatic Arthritis: Novel Developments > Selective IL-23 inhibition: a new option in active PsA

Selective IL-23 inhibition: a new option in active PsA

Presented By
Prof. Andrew Östör, Monash University, Australia
ACR 2021
Phase 3, KEEPsAKE 1, KEEPsAKE 2
Results of the KEEPsAKE 1 and 2 trials demonstrated high efficacy of the IL-23 blocker risankizumab in adult patients with active psoriatic arthritis (PsA), independent of previous therapy. Risankizumab also showed an excellent safety profile. The selective IL-23 inhibitor risankizumab has already been approved for moderate-to-severe psoriasis and is being investigated as a treatment for adults with PsA. At the ACR meeting, 2 presentations covered the phase 3 KEEPsAKE trials, which compared risankizumab with placebo [1,2]. In a plenary session, Prof. Andrew Östör (Monash University, Australia) presented an integrated analysis of data from the KEEPsAKE 1 (NCT03675308) and KEEPsAKE 2 (NCT03671148) studies, including 1,407 patients with active PsA who had inadequate res...

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