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Bisphosphonate use: Asian American women have a smaller treatment benefit

Presented By
Prof. Jinoos Yazdany, University of California San Francisco, USA
Conference
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A large observational study showed that the reduction of clinical fractures by bisphosphonates outweighs the risk of bisphosphonate-associated atypical femur fractures. However, Asian Americans have a higher risk for these fractures, thus diminishing their advantage of therapy, in particular in the long term. Concerning patient safety, Prof. Jinoos Yazdany (University of California San Francisco, USA) selected a study on bisphosphonates in her lecture ‘Year in review’ as particularly relevant for daily practice [1]. Although bisphosphonates are effective in reducing osteoporotic fractures, concerns about atypical femur fractures (AFFs) have contributed to substantially decreased bisphosphonate use. To further explore these uncertainties, a large observational study was performed including 196,129 women ≥50 years of age that received bisphosphonates [2]. All patients were members of the Kaiser Permanente Southern California healthcare system and were follow...


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