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Inflammatory disease as a risk factor for fractures

Presented By
Dr Giovanni Adami, University of Verona, Italy
ACR 2020
An Italian cohort study in women with inflammatory diseases such as rheumatoid arthritis  discovered an increased fracture risk that was not associated with the use of corticosteroids. “We all know that glucocorticoid-induced osteoporosis is the most common form of secondary osteoporosis and is associated with an increased risk of fragility fracture,” stated Dr Giovanni Adami (University of Verona, Italy) [1]. “Nonetheless, we use glucocorticoids in several inflammatory diseases and, currently, the independent role of the inflammation or glucocorticoid use on fracture risk in such patients is still unknown,” he continued to explain the motivation for the current retrospective, observational cohort study. Data was collected from the Italian web-based nationwide tool for fracture risk assessment, DeFRAcalc [2]. The analysis was performed by propensity score matching in a cohort of 59,950 women, ~10,000 of them sufferi...

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