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Zinc may worsen rheumatoid arthritis, lab study suggests


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Journal
Science Signaling
Reuters Health - 18/01/2022 - Zinc supplementation may exacerbate rheumatoid arthritis (RA), new laboratory data suggest. In monocytes from patients with RA, researchers found high concentrations of intracellular zinc, which regulates immune responses by affecting signaling pathways, according to a report in Science Signaling. They also found increased expression of Zip8, a zinc-specific importer, in peripheral and synovial monocytes of patients with RA and zinc-mediated metabolic shift. These shifts are "closely associated with enhanced proinflammatory cytokines," Dr. Won-Woo Lee of Seoul National University College of Medicine told Reuters Health by email. "Among 14 zips, zip8 expression was uniquely increased in peripheral and synovial monocytes," Dr. Lee explained "Zip8-mediated zinc influx in these cells was important for the inflammatory response, such as the production of the proinflammatory cytokine IL-1beta." Further, he said, "We found that z...


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