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Antiseptic drug comparable to antibiotics for recurrent UTIs in women


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Journal
The BMJ
Reuters Health - 15/03/2022 - Prophylaxis with the antiseptic methenamine hippurate was non-inferior to antibiotic prophylaxis among women with recurrent urinary tract infections (UTIs) in a multicenter, open-label randomized trial. "This trial should certainly be looked at by guideline writers and policy makers alike and may alter current recommendations," Dr. Chris Harding of Freeman Hospital/Newcastle upon Tyne, UK, told Reuters Health by email. "The study demonstrates equivalent efficacy in terms of UTI prevention when methenamine is compared to the current guideline-recommended standard treatment of daily low-dose preventative antibiotics in a well-defined population of women suffering recurrent UTI episodes." "Previous work has suggested that methenamine may be useful, but this trial provides further high-quality evidence and quantification of efficacy," he said. "The pragmatic methodology allows generalizability of results, as the population studied represent...


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