Home > Oncology > Drop in PSA tied to better outcomes of apalutamide therapy in prostate cancer

Drop in PSA tied to better outcomes of apalutamide therapy in prostate cancer


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Journal
European Urology
Reuters Health - 30/12/2021  - Adding apalutamide to androgen-deprivation therapy (ADT) leads to a fast, sustained drop in prostate-specific antigen (PSA) levels in patients with nonmetastatic castration-resistant prostate cancer (nmCRPC), and this reduction is linked with better outcomes, according to a post hoc analysis of data from the SPARTAN trial. "The study confirmed that the onset and depth of PSA reductions observed after initiating treatment with apalutamide are indeed associated with the outcomes most important to us clinically, including metastasis-free survival and overall survival," said Dr. Jeffrey J. Tosoian, an assistant professor in the division of urologic oncology at Vanderbilt University Medical Center in Nashville, Tennessee. "PSA levels early in the course treatment with apalutamide can provide important information regarding longer-term outcomes, further supporting the use of PSA testing to monitor treatment response," Dr. Tosoian, who was no...


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