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Residual tumour resection in case of elevated markers

Presented By
Dr Yue Che, University of Düsseldorf, Germany
EAU 2021
In patients with germ cell tumours and elevated serum tumour markers, whether post-chemotherapy residual tumour resection is beneficial is unclear. A retrospective analysis from Germany aimed to better define patients who benefit from surgery in this setting. By analysing data from their own database, Dr Yue Che (University of Düsseldorf, Germany) and colleagues found 575 post-chemotherapy residual tumour resections, performed in 516 patients, including 153 procedures in patients with elevated serum tumour markers (human chorionic gonadotropin [β-HCG] >2.0 mIU/mL; α-fetoprotein [AFP] >7.0 µg/L). Of these patients, 55 received resection after first-line chemotherapy and 98 after second- or further-line (salvage) chemotherapy [1]. Viable cancer in the resected specimen was more frequently present in the salvage group compared with the first-line group (49% vs 16%; P=0.0002). The presence of viable cancer was a predictor of survival in both group...

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