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Worse renal function after radical versus partial nephrectomy

Presented By
Prof. Francesco Trevisani, IRCCS Ospedale San Raffaele, Milan, Italy
Conference
EAU 2021
Both radical and partial nephrectomy harbour a non-negligible risk of post-operative chronic kidney disease (CKD) events, even in patients with normal renal function at 5 years post-surgery. However, radical nephrectomy patients tend to compensate the acute loss of renal function derived from the absence of the contralateral kidney with an increase of estimated glomerular filtration rate (eGFR), whereas eGFR in partial nephrectomy patients tends to remain stable over time. CKD represents a major post-operative long-term complication in renal surgery for renal cell cancer (RCC). This is the case both for radical and partial nephrectomy and despite major advances in surgical techniques. Whether the renal hyperfiltration mechanism after an acute loss of nephron mass could promote a compensatory process over time in oncological patients is still under debate. Therefore, a retrospective study by Prof. Francesco Trevisani (IRCCS Ospedale San Raf...


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