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Platinum-based therapy could be helpful in some with advanced prostate cancer


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Journal
JAMA Network Open
Reuters Health - 05/11/2020 - Platinum-based treatment is associated with antitumor activity in patients with advanced prostate cancer with DNA-repair-gene aberrations, according to a multinational group of researchers. Genomic aberrations that impair DNA-repair genes occur at a frequency of up to 30% in advanced prostate cancer, Dr. Sabine Schmid of Princess Margaret Cancer Centre, in Toronto, Canada, and colleagues note in JAMA Network Open. Some have been associated with sensitivity to platinum compounds and/or PARP inhibitors. To find out if platinum-based therapy might be beneficial in patients with castration-resistant prostate cancer (CRPC), as it is known to be in certain patients with triple-negative breast cancer, the team examined data on 508 patients from 25 academic centers in 12 countries. The men's median age was 61 years. For most patients (65%), there were no data on DNA-repair-gene aberrations, but such aberrations were found to be present i...


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