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Targeting glutamine could curb castration-resistant prostate cancer


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Journal
Proceedings of the National Academy of Sciences of the United States of America
Reuters Health - 29/03/2021 - Targeting glutamine, rather than the androgen receptor (AR), successfully inhibited tumor growth in experiments in prostate cancer cells, tissue and animal models, potentially paving the way to clinical trials, researchers say. "The current treatment strategy targeting the AR causes serious side effects and the tumors will eventually develop resistance," Dr. Jiaoti Huang of Duke University School of Medicine in Durham, North Carolina, told Reuters Health. "Directly targeting tumor cell metabolism and avoiding the complex AR signaling network has the potential to avoid the side effects," he said by email, "and it will be more difficult for tumor cells to develop resistance mechanisms." "Patients with the advanced and aggressive forms of prostate cancer, such as small cell neuroendocrine carcinoma, should be better suited for this potential therapy since these tumors are more addicted to glutamine," he noted. Dr. Huang and c...


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