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Three months of daily sublingual therapy cuts UTI recurrences by more than half


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Journal
NEJM Evidence
Reuters Health - 03/02/2022 - A collection of inactivated bacteria, given sublingually for three months, can dramatically reduce the risk of urinary-tract infection in women who have recurrent episodes. In a randomized test of 240 women in Spain and the United Kingdom, three months of daily administration of the experimental treatment, known as MV140, helped keep 56% of women free of UTIs for one year compared to 25% of the women treated with placebo, a significant difference. A third group of women received the inactivated bacteria for six months, but the longer duration didn't seem to produce a significantly better outcome - 58% were UTI-free by the end of the study. "Women receiving MV140 experienced a sustained improvement" in their quality of life, said the team, led by Dr. Maria-Fernanda Lorenzo-Gomez of University Hospital of Salamanca, in Spain. Although the treatment is given every day for months, the researchers are characterizing it as a vac...


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